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AVIAN INFLUENZA

Table of Contents

What is Avian Influenza (AI)?
Background
How is the disease spread?
Potential Human Impact
Clinical Signs in Poultry

Surveillance and Testing Program
AI Biosecurity
Definitions
Links






What is Avian Influenza (AI)?
Avian Influenza Virus is a Type A Influenza virus. There are 15 subtypes of influenza virus known to infect birds. These subtypes are classified as “H” or “N”. Type A Influenza viruses can affect humans (H1N1, H1N2, H2N2), horses (H3N8, H7N7), pigs and many bird species. There are two forms of the type A Influenza viruses that affect birds, Low Pathogenic Avian Influenza (LPAI) and High Pathogenic Avian Influenza (HPAI).

Frequently Asked Questions about Avian Influenza

NJ Department of Agriculture Letter to Poultry Producers

USDA Avian Influenza Information

USDA Efforts and Response To Avian Influenza in the United States

USDA Avian Influenza Fact Sheet


Official U.S. government Web site for information on pandemic flu and avian influenza


Background
Outbreaks in Asia have resulted in the death and depopulation of millions of birds and morbidity and mortality in people with direct contact with infected birds. LPAI is not typically as virulent as HPAI. However, research has shown that AI viruses of low pathogenicity can mutate into highly pathogenic viruses (antigenic drift). Some strains of HPAI can infect humans. Scientists are concerned about the potential for the virus to acquire human influenza genes and develop the ability to tranmsit from human to human. Therefore, it is important to control the spread of avian influenza through the use of personal protective equipement and biosecurity. During the 1983-84 AI epidemic in Pennsylvania poultry, the H5N2 virus initially caused low mortality, but within 6 months became highly pathogenic, with a mortality approaching 90 percent. Control of this outbreak required destruction of more than 17 million birds at a cost of nearly $65 million dollars. In March 2004 evidence of a low and high pathogenicity avian influenza virus was detected on a broiler-breeder farm in Canada. Although only 3 million birds were destroyed in this epidemic compared to the 17 million destroyed in Pennsylvania, it has been estimated that the outbreak in Canada will cost farmers approximately $340 million to rebuild the industry. In addition to the negative economic impact to the poultry industry, the cost of an outbreak also includes depopulation and disposal of bird carcasses, labor, cleaning, disinfection, and premises or business downtime.



How is the disease spread?
Both forms of AI are highly contagious and are spread through movement of infected birds, infected droppings, contaminated clothing, materials, and equipment. Wild waterfowl are believed to be the reservoir of Avian Influenza, shedding the virus in their feces without clinical signs of disease. An outbreak in migrating waterfowl in China has caused concern due to the large numbers of deaths and the fact that the waterfowl will spread the virus with migration. This disease is important because it leads to a decrease in egg productivity and can cause high morbidity and mortality.

Pictured: The influenza virus, as well as the antigens (small spikes) on the viral particle surface. These antigens are what stimulate the immunological response in the host (bird, human, etc.)





Potential Human Impact
LPAI viruses have the ability to mutate into HPAI strains that can infect humans. These strains of HPAI are the source of pandemic outbreaks where a new subtype of the virus is created and can be transmitted between humans or an older subtype of the virus resurfaces that hasn't been detected or transmitted for years. Influenza pandemics in the past have caused severe illness and death in humans and substantial economic loss.

The New Jersey Department of Health and Senior Services has a comprehensive website regarding Influenza, a viral infection of the respiratory system, which includes the nose, throat, bronchial tubes and lungs.
www.state.nj.us/health/flu/index.shtml


Centers for Disease Control and Prevention
www.cdc.gov/flu/avian/gen-info/avian-flu-humans.htm
www.cdc.gov/flu


World Health Organization Avian Influenza Updates
www.who.int/csr/disease/avian_influenza/en



Clinical Signs in Poultry
Low Pathogenic Avian Influenza:

- Little or no clinical signs
- Mild respiratory disease (coughing and sneezing)
- Decreased egg production


High Pathogenic Avian Influenza:

- Sudden death without clinical signs
- Lack of energy and appetite
- Nasal Discharge
- Coughing and sneezing
- Decreased Egg Production
- Swelling of the head, eyelids, combs, wattles and hocks
- Purple discoloration of the wattles, combs and legs
- Incoordination
- Diarrhea
- Soft-shelled or misshapen eggs




Clinical signs of Avian Influenza include swelling of the head, respiratory distress such as excessive coughing and sneezing (left), decreased food consumption, and purple discoloration of the wattles, combs and legs (rightt).








Surveillance and Testing Program
The New Jersey Department of Agriculture, Division of Animal Health has been doing active surveillance and testing of birds for Avian Influenza within the state for over 20 years. Surveillance is conducted on backyard flocks, at livestock and poultry auctions, poultry distributor facilities and live bird markets. Testing for AI is performed in order to allow for early detection and elimination of the virus if it is found.

If you would like more information regarding AI flock testing contact the Division of Animal Health at (609) 292-3965.



Avian Influenza Biosecurity
The New Jersey Department of Agriculture has an emergency response plan in place for the rapid control and elimination of the virus during outbreaks of both LPAI and HPAI. The plan includes provisions for limiting the spread of the disease through increased biosecurity including limiting the traffic to and from the infected premise, increased surveillance in designated quarantine zones, rapid turn around time for submitted samples and depopulation and vaccination procedures for infected birds.

Good biosecurity is one of the best ways to prevent and control the spread of any disease. Many people don’t realize that diseases can be carried on clothing, equipment, or vehicles. Here are some ways to keep your birds healthy:

Wear clean clothing that has been washed with laundry detergent, and boots that have been cleaned and disinfected. Also make sure that anyone else entering your property follows these guidelines because disease can be easily spread by clothing shoes and hands that have contact with the birds. Some examples of disinfectants would be Roccal, Nolvasan, Household bleach, Lysol spray for footwear, and Purell for hand disinfection.



These men are practicing proper biosecurity by preventing the transmission of disease by debris carried on footwear and clothing. This includes disinfecting footwear before and after working with the birds (left), or keeping a separate pair of shoes (such as the over-the-shoe boots seen above) to work around birds and changing into other shoes when leaving the premise (right). This also includes wearing coveralls, like the man on the right, which can be removed when leaving the premise and easily cleaned.




Make sure all equipment that had contact with the poultry, such as lawn, garden and poultry equipment, is washed and disinfected before taken to another place. You should follow the same procedure when you bring your equipment back onto your property so no diseases are brought on from somewhere else.

Only allow your employees to handle the birds on a day-to-day basis. Make sure that these employees don’t own a commercial or private bird operation themselves, because this could lead to the spread of disease.

Do not visit any other poultry farms or places where birds may be kept. If you attend shows or fairs, keep from coming in contact with other poultry owners, because they may not follow the same biosecurity measures that you do.


An important part of biosecurity is recognizing the various ways that disease can spread from farm to farm. This includes carrying debris (mud, droppings, etc) on vehicle tires and even on tools such as feed scoops, shovels, and brooms. To prevent the spread of germs, clean and disinfect these items between uses/premises.


Wild birds such as geese, ducks and game birds can be carriers of infectious disease. It is very important to try to prevent these birds from coming in contact with your poultry.

Practice the “all in-all out” policy with poultry. Each lot of birds should be processed separately. Try not to leave birds behind because they have a better chance of contracting a disease because of their prolonged exposure. It also is good practice to clean and allow sufficient downtime in between flocks.

Knowing the warning signs of an infectious disease is very important. If bird owners are familiar with the symptoms of diseases, they will be able to prevent further spread into their flocks. If any of the signs listed above are found in your birds, it is important that you contact your veterinarian or State, Federal, or local agriculture officials immediately.



Definitions

Antigenic Drift (1)-
the process of “evolutionary” changes in molecular structure of DNA/RNA in microorganisms during their passage from one host to another; it may be due to recombination, deletion, or insertion of genes, point mutations or combinations of these events; it leads to alteration (usually slow and progressive) in the antigenic composition, and therefore in the immunologic responses of individuals and populations to exposure to the microorganism concerned.
Biosecurity (2)-
all the cumulative measures that can or should be taken to keep disease (viruses, bacteria, fungi, protozoa, parasites) from a farm and to prevent the transmission of disease (by humans, insects, rodents, and wild birds/animals) within an infected farm or to neighboring farms.
Morbidity (3)-
a diseased state.
Mortality (4)-
death. Also, the number of deaths in a given time or place or the
proportion of deaths to population.
Reservoir (of infection) (5)-
living or nonliving material in or on which an infective agent multiplies and/or develops and is dependent for its survival in nature.

1,3,5:
Stedman’s Medical Dictionary, 27th edition. 2000.
2:
Hegni, Dr. Fidelis (USDA,APHIS,Veterinary Services). 2004. Overview of Biosecurity and Avian Influenza. www.cdc.gov/flu/pp/biosecurity_on_farm_11_2004.pdf
4:
Merriam Webster’s Collegiate Dictionary, 11th edition.



Links

For general information on Avian Influenza:

Centers For Disease Control and Prevention
www.cdc.gov/flu/avian/index.htm
www.cdc.gov/flu/avian/gen-info

Animal and Plant Health Inspection Service (APHIS)- Hot Issues-Avian Influenza
www.aphis.usda.gov/lpa/issues/issues_archive/ai_us/ai_us.html

APHIS Avian Influenza Fact Sheet

www.aphis.usda.gov/lpa/pubs/fsheet_faq_notice/fs_ahhpaiplan.html


World Organization for Animal Health (OIE)

www.oie.int/eng/en_index.htm

Bird flu articles from the science journal Nature
www.nature.com/nature/focus/avianflu/index.html


For information on Biosecurity:

APHIS-Biosecurity for the Birds
www.aphis.usda.gov/vs/birdbiosecurity



For information on Poultry Importation and Fair Regulations for Neighboring States:


New York: www.agmkt.state.ny.us/AI/AIHome.html
Pennsylvania: www.agriculture.state.pa.us/agriculture/cwp/view.asp?a=3&q=127347&agricultureNav=|
Delaware:www.state.de.us/deptagri/poultryah/index.shtml
Maryland: www.mda.state.md.us/animal_health

For additional states’ regulations, contact that state’s Department of Agriculture.
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